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Narcissu 2 is set about six or seven years before the events of the original Narcissu, while Setsumi was still just a regular outpatient living at home near the hospital.

We meet Himeko, a former 7th floor helper at the hospital. Cheerful and full of energy, no one expected that she would one day be a patient in the same ward that she had spent so much time volunteering at. One summer day, while Setsumi was going to the hospital for an examination, Setsumi meets Himeko, and a long summer begins…